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KMID : 0644120060190040093
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Journal of Oriental Gynecology
2006 Volume.19 No. 4 p.93 ~ p.116
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Effects of Hwaganjeon on Immobilization-Stress or Cold-Stress in Mice
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Park Jong-Moon
Ahn Kyu-Hwan
Choe Chang-Min
Yoo Sim-Keun
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Abstract
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Purpose : This study is to examine the effects of Hwaganjeon water extract(HGJ) on immobilization-stress or cold-stress in BALB/C mice.
Methods : We have Hwaganjeon water extract(HGJ) by freeze-dryer & melt it by a saline solution. We feed HGJ 500mg/Kg to 5mice, and add immobilization-stress by putting mice in plastic cylinder 10 hours, and add cold-stress by putting mice in 4^{circ}C cold room 6 hours.
Results : 1. HGJ decreased the serum level of histamine and corticosterone increased by immobilization-stress or cold-stress. HGJ inhibited the release of histamine from mast cells at the concentration of 1 mg/ml. 2. HGJ did not affect the cell viability of thymocytes decreased by immobilization-stress or cold-stress, but increased the cell viability of splenocytes decreased by immobilization-stress or cold-stress. 3. HGJ decreased the population of splenic CD4^{+} and CD8^{+}$cells increased by immobolization-stress or cold-stress. 4. HGJ enhanced the production of {gamma}-interferon(IFN) and interleukin(IL)-2 decreased by immobilization-stress or cold-stress.
Conclusion : These results indicate that HGJ may be useful for the prevention and treatment of stress via suppression of serum histamine and corticosterone level and enhancement of immune response.
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KEYWORD
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Hwaganjeo(HGJ), immobilization-stress, cold-stress, histamine, corticosterone, immune response
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